Rapid hydrolysis of phosphate monoesters by zirconium(IV) complexes in neutral solution
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منابع مشابه
Catalytic Zinc Complexes for Phosphate Diester Hydrolysis**
Creating efficient artificial catalysts that can compete with biocatalysis has been an enduring challenge which has yet to be met. Reported herein is the synthesis and characterization of a series of zinc complexes designed to catalyze the hydrolysis of phosphate diesters. By introducing a hydrated aldehyde into the ligand we achieve turnover for DNA-like substrates which, combined with ligand ...
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Diverse species have previously been proposed to be effective nucleophiles in the enzymatic hydrolysis of phosphate esters. A novel penta-metal cluster (two Fe(3+) and three Ca(2+)) was recently discovered in the active site of PhoX alkaline phosphatase, with the revelation of the architecture of μ3-oxo bridging one Ca(2+) and two antiferromagnetically coupled Fe(3+). In this work, using densit...
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Kinetics of the cleavage of two phosphate diesters, bis(4-nitrophenyl) phosphate and 2-hydroxypropyl 4-nitrophenyl phosphate and a triester, 4-nitrophenyl diphenyl phosphate, in the presence of Mg(II), Ca(II) and Sr(II) were studied in 90% vol. DMSO at 37 degrees C. The alkaline hydrolysis of the triester was inhibited by all cations, but with both phosphodiesters strong catalytic effects were ...
متن کاملHydrolysis of S-substituted monoesters of phosphorothioic acid by alkaline phosphatase from Escherichia coli.
Alkaline phosphatase from Escherichia coli catalyzes the hydrolysis of S-substituted monoesters of phosphorothioic acid of the type RSP03Naz (R = -CH2CH2NH2,-CH2CHzNHCOCH3,-CH,COOH, or -CH2CHzCOOCzH~), at the S-P bond, to yield orthophosphate and the corresponding thioalcohols. The rate of enzymic hydrolysis of cysteamine S-phosphate was measured at different pH values and substrate concentrati...
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ژورنال
عنوان ژورنال: Polyhedron
سال: 2012
ISSN: 0277-5387
DOI: 10.1016/j.poly.2012.09.015